E-mail: zhaojinhua@mail.kib.ac.cn
Education
1996.6-1999.6: Ph.D., Zoology (Natural Pharmacy), School of Life Sciences, Sun Yat-sen University
1993.9-1996.6: M.Sc., Physiology (Cardiovascular Pharmacology), School of Life Sciences, Sun Yat-sen University
1988.9-1990.6: B.Sc. Department of Biology, Anhui Education College
1981.9-1984.6: Study in Wuwei Normal School, Anhui Province.
Professional Experiences
2015-present: Professor, Institute of Pharmacology, School of Pharmaceutical Sciences, South-Central University for Nationalities
2010-2018: Professor, Kunming Institute of Botany, Chinese Academy of Sciences
1999-2010: Senior Manager & Senior Researcher, Technology Center of Shenzhen Neptunus Group Co., Ltd.
1984-1993: Taiping Junior Highschool, Wuwei County, Anhui Province.
Team
Dr. Yin Ronghua, Lecturer
Dr. Gao Na, Lecturer
Research Interests
Evaluation of the activity of natural products on cardiovascular system, investigation of the mechanism of these active compounds, and discovery and development of new drugs.
Recently, our research focuses on investigation of the precise chemical structure and structural modification of complex natural polysaccharides with repetitive structural units, their cardiovascular activity, pharmacological mechanisms and structure-activity relationships.
Major Research Progress
In the chemical and pharmacological researches on fucosylated glycosaminoglycan (FG), we established several depolymerization methods which could highly-selectively cleave the special glycosidic bonds in FG backbone. Based on the bottom up strategy, the precise structures of native FGs from various species of sea cucumber have been well-defined by the preparation of depolymerized products and the purification and structural analysis of the resulting oligosaccharides. A series of pure FG-derived oligosaccharides with different reducing or non-reducing end residues and their derivatives with structural modification were obtained for investigation of the pharmacological activity and structure-activity relationships.
By systematically evaluating the anticoagulant and antithrombotic activities of native FG, its depolymerized products and pure oligosaccharides, we elucidated the structure-activity relationship and essential structural characteristics of FG fragments for selective and potent inhibition of intrinsic factor tenase complex (F.Xase), and also elucidated the F.Xase inhibition mechanisms of FG by investigation of tenase enzymatic kinetics in the presence of FG oligosaccharides and by investigation of the affinity and dynamic processes of interaction of FG with the target protein.
Based on the anticoagulant activity of native FGs and their derivatives, a new anti-coagulant and anti-thrombotic drug, LFG (novel chemical entity), which is a potent and selective inhibitor of intrinsic Xase, is in preclinical development under combination with a famous pharmaceutical company. Compared with enoxaparin which is a clinical first-line drug, LFG has the advantage of lower risk of bleeding. A series of pertinent patents related to LFG have been authorized by China, the United States, Japan and other countries. Based on these results, the investigational new drug candidate LFG53 has been granted clinical trial approval by both the FDA and NMPA.
During the period in the National Technology Center of Shenzhen Neptunus Group Co., Ltd., I was responsible for innovative drug research and development and established an experimental research platform for drug discovery. The representative achievements include: a State first class new drug - Polydatin Injection (approved for clinical trials by the CFDA and FDA), a fifth-class new drug - Aixintong Tablets (approved for clinical trials by the Chinese FDA), improvement of a Traditional Chinese medicine -Biyuan Soft Capsule (licensed for marketing) etc.
More than 70 papers have been published in domestic and international academic journals such as PNAS, JBC, Eur J Med Chem, Thromb Haemost, Carbohydr Polym, BBA, Angew Chem Int Ed, Chem Eur J, Thromb Res, Mar Drugs, etc. More than 60 patents have been applied, among which, more than 50 invention patents have been authorized by China, the United States, Japan, Australia, and other countries.
Our research projects are supported by more than twenty foundations, with resources from Nation, Academy and Province, including the National Major Special Project for “Significant New Drugs Development”, the 863 Project and the Guiding Project, the Major Project of the National Development and Reform Commission, the Technology Innovation Project of the Ministry of Science and Technology, the Innovative Medicine Project of the CAS Chinese Academy of Sciences, the Natural Product Application Transformation Project of the CAS Chinese Academy of Sciences, the Key breakthrough projects in key areas of Guangdong and Hong Kong, the Shenzhen-Hong Kong Innovation Circle Project, the Guangdong Province Ministry of Education Industry-University-Research Project, the Key Project of Yunnan Province Applied Basic Research Program, and the Yunnan Key New Product Project.
Selected Recent Publications:
Cui LG, Sun HF, Shang XL, Wen J, Li PF, Yang ST, Chen LX, Huang XY, Li HY, Yin RH*, and Zhao JH. Purification and structural analyses of sulfated polysaccharides from low-value sea cucumber Stichopus naso and anticoagulant activities of its oligosaccharides. Marine Drugs. 2024; 22: 265.
Ma Y, Zuo ZC, Zheng WQ, Yin RH, Wu XW, Ma YJ, Ji MC, Ma WW, Li X*, Xiao WL**, Gao N***, Zhao JH. Structural characterization of a distinct fucan sulfate from Pattalus mollis through an oligosaccharide mapping approach. Carbohyd Res., 2024, 536:109052.
Chen R, Wang WL, Yin RH, Pan Y, Xu C, Gao N*, Luo XD*, and Zhao JH. Structural characterization and anticoagulant activities of a keratan sulfate-like polysaccharide from the sea cucumber Holothuria fuscopunctata. Mar Drugs. 2023, 21: 632.
Lan D, Zhang JL, Shang XL, Yu LJ, Xu C, Wang P, Cui LG, Cheng NQ, Sun HF, Ran JN, Sha L, Yin RH, Gao N*, Zhao JH*. Branch distribution pattern and anticoagulant activity of a fucosylated chondroitin sulfate from Phyllophorella kohkutiensis. Carbohyd Polym. 2023, 321:121304.
Ruzemaimaiti D#, Sun HF#, Zhang JL, Xu C, Chen LX, Yin RH*, Zhao JH*. Oligomer-guided recognition of two fucan sulfate from Bohadschia argus and inhibition of P-selectin binding to its ligand. Carbohyd Polym. 2023, 317:121080.
Sun HF, Yang SS, Li PF, Shang XL, Wang P, Zhang JL, Yuan L, Yin RH, Gao N*, Zhao JH*. Comparative assessment of APTT reagents for evaluating anticoagulant sensitivity of fucosylated glycosaminoglycans (FGs) derived from sea cucumbers. Mar Drugs. 2023, 21: 568.
Zuo ZC, He ZC, Ma Y, Xu C, Tao XL, Ning ZM, Gao L, Rehemiding A, Gao N*, Zhao JH*. Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota. Int J Biol Macromol. 2023, 236: 123935.
Li SJ, Wang WL, Lin LS, Yang L, Cai Y, Yang XZ, Zhang TC, Xiao C, Yan H, Gao N*, Zhao JH*. Oligosaccharide blocks PAR1 (Proteinase Activated Receptor 1)-PAR4–mediated platelet activation by binding to thrombin exosite II and impairs thrombosis. Arterioscler, Thromb, Vasc Biol. 2023, 43:253-266.
Xia F#, Lin LS#, Ye YS#, Yang L, Zhao JH*, Xu G*. 11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii. Bioorg Chem. 2023, 140:106834.
Dai MY, Peng W, Lin LS, Wu, ZXE, Zhang T, Zhao Q, Cheng Y, Lin QX, Zhang BB, Liu AM, Rao QR, Huang JF, Zhao JH*, Gonzalez FJ*, Li F*. Celastrol as an intestinal FXR inhibitor trigger tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. Phytomedicine. 2023, 121: 155054.
Wang WL#, Mao H#, Li SJ, Zhang LL, Yang L, Yin RH*, Zhao JH*. Branched chondroitin sulfate oligosaccharides derived from the sea cucumber Acaudina molpadioides stimulate neurite outgrowth. Mar Drugs. 2022, 20: 653.
Tao XL, Wang WL, Shi X, Lan D, Mao H, Ning ZM, Gao L, Zuo ZC, Xu C, Yang ZQ, Wang Y, Zuo ZL, Gao N*, Zhao JH*. Peroxidative depolymerization of fucosylated glycosaminoglycan: Bond-cleavage pattern and activities of oligosaccharides. Carbohyd Polym. 2022, 295:119855.
Yin RH, Pan Y, Cai Y, Yang F, Gao N, Ruzemaimaiti D, Zhao JH*. Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea. Carbohyd Polym. 2022, 294: 119826.
Li XM, Sun HF, Ning ZM, Yang WJ, Cai Y, Yin RH*, Zhao JH*. Mild acid hydrolysis on Fucan sulfate from Stichopus herrmanni: Structures, depolymerization mechanism and anticoagulant activity. Food Chem. 2022, 395: 133559.
Liu XX, Ning ZM, Zuo ZC, Wang P, Yin RH, Gao N*, Wu B, Zhao JH. The glycosidic bond cleavage and desulfation investigation of fucosylated glycosaminoglycan during mild acid hydrolysis through structural analysis of the resulting oligosaccharides. Carbohyd Res. 2022, 511: 108493.
Gao L, Xu C, Tao XL, Zuo ZC, Ning ZM, Wang LH, Gao N*, Zhao JH*. Structure elucidation of fucan sulfate from sea cucumber Holothuria fuscopunctata through a bottom-up strategy and the antioxidant activity analysis. Int J Mol Sci. 2022, 23: 4488.
Ning ZM, Wang P, Zuo ZC, Tao XL, Gao L, Xu C, Wang ZY, Wu B*, Gao N*, Zhao JH. A fucan sulfate with pentasaccharide repeating units from the sea cucumber Holothuria floridana and its anticoagulant activity. Mar Drugs. 2022, 20: 377.
Li XM, Li SN, Liu J, Lin LS, Sun HF, Yang WJ, Cai Y, Gao N, Zhou LT, Qin HB*, Yin RH*, Zhao JH*. A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity. Carbohyd Polym. 2021, 256: 117513.
Li SN, Zhong W, Pan Y, Lin LS, Cai Y, Mao H, Zhang TC, Li SJ, Chen R, Zhou LT, Wang WL, Cui QH*, Yin RH*, Huang SX*, Zhao JH*. Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis. Carbohyd Polym. 2021, 269: 118290.
Zhou LT, Yin RH, Gao N, Sun HF, Chen DY, Cai Y, Ren L, Yang L, Zuo ZL*, Zhang HB*, Zhao JH*. Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis. Pharmacol Res. 2021, 166: 105527.
Chen R, Yin RH, Li SN, Pan Y, Mao H, Cai Y, Lin LS, Wang WL, Zhang TC, Zhou LT, Gao N*, Luo XD*, Zhao JH*. Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization. Carbohyd Polym. 2021, 270: 118368.
Yin RH, Zhou LT, Gao N, Lin LS, Sun HF, Chen DY, Cai Y, Zuo ZL, Hu KF, Huang SX*, Liu JK*, Zhao JH*. Unveiling the disaccharide-branched glycosaminoglycan and anticoagulant potential of its derivatives. Biomacromolecules. 2021, 22(3): 1244-55.
Ma Y, Gao N, Zuo ZC, Li SN, Zheng WQ, Shi X, Liu QP, Ma T, Yin RH*, Li X*, Zhao JH*. Five distinct fucan sulfates from sea cucumber Pattalus mollis: Purification, structural characterization and anticoagulant activities. Int J Biol Macromol. 2021, 186: 535.
Shi X#, Guan RW#, Zhou LT, Zuo ZC, Tao XL, Wang P, Zhou YR, Yin RH, Zhao LY*, Gao N*, Zhao JH. Structural characterization and heparanase inhibitory activity of fucosylated glycosaminoglycan from Holothuria floridana. Mar Drugs. 2021, 19(3): 162.
Liu S #, Zhang TC #, Sun HF, Lin LS, Gao N, Wang WL, Li SJ, Zhao JH *. Pharmacokinetics and pharmacodynamics of a depolymerized glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in rats by bioanalytical methods. Mar Drugs. 2021, 19: 212.
Lin LS, Li SJ, Gao N, Wang WL, Zhang TC, Yang L, Yang XZ, Luo D, Ji X*, Zhao JH*. The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants. Mar Drugs. 2021, 19(9): 487-499.
Lin LS, Yang L, Chen J, Zhou LT, Li SJ, Gao N, Zhao JH*. High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on αIIbβ3 and platelet secretion. Platelets. 2021, 32(7): 975.
Mao H#, Cai Y#, Li SN, Sun HF, Lin LS, Pan Y, Yang WJ, He ZC, Chen R, Zhou LT, Wang WL, Yin RH*, Zhao JH*. A new fucosylated glycosaminoglycan containing disaccharide branches from Acaudina molpadioides: Unusual structure and anti-intrinsic tenase activity. Carbohyd Polym. 2020, 245: 116503-12.
Yang WJ#, Chen DY#, He ZC, Zhou LT, Cai Y, Mao H, Gao N*, Zuo ZL*, Yin RH*, Zhao JH. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber. Carbohyd Polym. 2020, 233: 115844-52.
Lin LS, Zhao LY, Gao N, Yin RH, Li SJ, Sun HF, Zhou LT, Zhao GL, Purcelle SW, Zhao JH*. From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors. Blood Reviews. 2020, 39: 100615.
Gao N, Chen R, Mou RR, Xiang JY, Zhou K, Li Z, Zhao JH*. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata. Int J Biol Macromol. 2020, 164: 3421–3428.
Sun HF#, Gao N#, Ren L, Liu S, Lin LS, Zheng WQ, Zhou LT, Yin RH, Zhao JH*. The components and activities analysis of a novel anticoagulant candidate dHG-5. Eur J Med Chem. 2020, 207:112796-801.
Zhou LT#, Gao N#, Sun HF, Xiao C, Yang L, Lin LS, Yin GH, Li Z, Zhang HB*, Ji X*, Zhao JH*. Effects of native fucosylated glycosaminoglycan, its depolymerized derivatives on intrinsic factor Xase, coagulation, thrombosis, and hemorrhagic risk. Thromb Haemost. 2020, 120(4):607-619.
Liu XX, Zhang ZX, Mao H, Wang P, Zuo ZC, Gao L, Shi X, Yin RH, Gao N*, Zhao JH*. Characterization of the hydrolysis kinetics of fucosylated glycosaminoglycan in mild acid and structure of the resulting oligosaccharides. Mar Drugs. 2020, 18: 286-302.
Luo D, Xu JP, Chen XJ, Zhu X, Liu S, Li J, Xu XT, Ma X*, Zhao JH*, Ji X*. EGCG attenuates salt-induced hypertension and renal injury in Dahl salt-sensitive rats. Sci Rep. 2020, 10: 4783-93.
Cai Y#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK, Liu SB, Yin RH*, Zuo ZL*, Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. Carbohyd Polym. 2019, 224:115146.
He ZC, Zhou LT, Lin LS, Yin RH*, Zhao JH*. Structure and heparanase inhibitory activity of a new glycosaminoglycan from the slug Limacus flavus. Carbohyd Polym, 2019, 220:176–184.
Yang WJ#, Cai Y#, Yin RH, Lin LS, Li ZK*, Wu MY*, Zhao JH*. Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber. Int J Biol Macromol. 2018, 115: 1055-1062.
Xiao C, Zhao LY, Gao N, Wu MY, Zhao JH*. Nonasaccharide inhibits intrinsic factor Xase complex by binding to factor IXa and disrupting factor IXa-Factor VIIIa interactions. Thromb Haemost. 2019, 19: 705–715.
Luo D, Chen X, Zhu X, Liu S, Li J, Xu J, Zhao JH*, Ji X*. Pu-Erh tea relaxes the thoracic aorta of rats by reducing intracellular calcium. Front Pharmacol. 2019, 10:1-13.
Zheng WQ, Zhou LT, Lin LS, Cai Y, Sun HF, Zhao LY, Gao N, Yin RH*, Zhao JH*. Physicochemical characteristics and anticoagulant activities of the polysaccharides from sea cucumber Pattalus mollis. Mar Drugs. 2019, 17(4): 198.
Guan RW, Peng Y, Zhou LT, Zheng WQ, Liu XX, Wang P, Yuan QX, Gao N, Zhao LY*, Zhao JH*. Precise structure and anticoagulant activity of fucosylated glycosaminoglycan from Apostichopus japonicus: Analysis of its depolymerized fragments. Mar Drugs. 2019, 17(4): 195.
Lin LS, Xu L, Xiao C, Zhou LT, Gao N, Wu MY, Zhao JH*. Plasma contact activation by a fucosylated chondroitin sulfate and its structure–activity relationship study. Glycobiology. 2018, 8(10): 754.
He HQ, Chen D, Li XM, Li CJ, Zhao JH *, Qin HB *. Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate. Org Biomol Chem.2019, 17: 2877.
Yin RH, Zhou LT, Gao N, Li Z, Zhao LY, Shang FN, Wu MY*, Zhao JH*. Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition. J Biol Chem. 2018, 293(36): 14089.
Shang FN#, Mou RR#, Zhang ZD#, Gao N, Lin LS, Li ZK, Wu MY*, Zhao JH*. Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors. Carbohyd Polym. 2018, 195: 257-266.
Zhang X, Liu H, Lin L, Yao W, Zhao JH, Wu MY*, Li ZJ*. Synthesis of fucosylated chondroitin sulfate nonasaccharide as a novel anticoagulant targeting intrinsic factor Xase complex. Angew Chem Int Ed. 2018, 57(39): 12880.
Zhao LY, Qin YJ, Guan RW, Zheng WQ, Liu JK,Zhao JH*. Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions. Carbohyd Polym. 2018, 186: 217-225.
Liu J, Zhou LT, He ZC, Gao N, Shang FN, Xu JP, Li Z, Yang ZM, Wu MY*, Zhao JH*. Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica. Carbohyd Polym. 2018, 181: 433-441.
Xu L#, Gao N#, Xiao C, Lin LS, Purcell SW, Wu MY*, Zhao JH*. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition. Eur J Med Chem. 2018, 154:133-143.
Shang FN#, Gao N#, Yin RH, Lin LS, Xiao C, Zhou LT, Li Z, Purcell SW, Wu MY*, Zhao JH*. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors. Eur J Med Chem. 2018, 148: 423.
Zhang X, Yao W, Xu XJ, Sun HF, Zhao JH, Meng XB, Wu MY, Li ZJ*. Synthesis of fucosylated chondroitin sulfate glycoclusters: a robust route to new anticoagulant agents. Chem.-Eur J. 2018, 24(7): 1694-1700.
Qin YJ, Yuan QX, Zhang YX, Li JL, Zhu XJ, Zhao LL, Wen J, Liu JK, Zhao LY,* Zhao JH*. Enzyme-assisted extraction optimization, characterization and antioxidant activity of polysaccharides from sea cucumber Phyllophorus proteus. Molecules. 2018, 23: 590.
Cai Y, Yang WJ, Yin RH, Zhou LT, Li ZK, Wu MY*, Zhao JH*. An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer. Carbohyd Res. 2018, 464: 12.
Li XM, Luo L, Cai Y, Yang WJ, Lin LS, Li Z, Gao N, Purcell SW, Wu MY*, Zhao JH*. Structural elucidation and biological activity of a highly regular fucosylated glycosaminoglycan from the edible sea cucumber Stichopus herrmanni. J Agric Food Chem. 2017, 65(42): 9315-9323.
Xiao C, Lian W, Zhou LT, GaoN, Xu L, Chen J, Wu MY*, Peng WL*, Zhao JH*. Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors, Thromb Res. 2016, 146: 59-68.
Zhao LY#, Wu MY#, Xiao C, Yang L, Zhou LT, Gao N, Li Z, Chen J, Chen JC, Liu JK*, Qin HB*, Zhao JH*. Discovery of an intrinsic tenase inhibitor, pure nonasaccharide from fucosylated glycosamino-glycan. PNAS. 2015, 112: 8284-8289.
Gao N#, Lu F#, Xiao C, Yang L, Chen J, Zhou K, Wen DD, Li Z, Wu MY, Jiang JM, Liu GM*, Zhao JH*. β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments. Carbohyd Polym. 2015, 127(3): 427–437;
Wu MY#, Wen DD#, Gao N, Xiao C, Yang L, Xu L, Lian W, Peng WL, Jiang JM*, Zhao JH*, Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase. Eur J Med Chem. 2015, 92: 257-269
Wu MY, Xu L, Zhao LY, Xiao C, Gao N, Luo L, Yang L, Li Z, Chen LY,* Zhao JH*. Structural analysis and anticoagulant activities of the novel sulfated fucan possessing a regular well-defined repeating unit from sea cucumber. Mar Drugs. 2015, 13: 2063-2084
Lian W, Huang N, Li Z, Zheng YT*, Peng WL*, Zhao JH*. Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope. Biochim Biophys Acta. 2013, 1830: 4681-4691.
Zhao LY#, Lai SS#, Huang R, Wu MY, Gao N, Xu L, Qin HB*, Peng WL*, Zhao JH. Structure and anticoagulant activity of fucosylated glycosaminoglycan degraded by deaminative cleavage. Carbohyd Polym. 2013, 98(2): 1514-1523.
Luo L, Wu MY, Xu L, Lian W, Xiang JY, Lu F, Gao N, Zhao JH*. Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers. Mar Drugs. 2013, 11: 399-417.
Huang N, Wu MY, Zheng CB, Zhu L, Zhao JH*, Zheng YT*. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry. Carbohyd Res. 2013, 380: 64-69.
Selected Authorized Invention Patent:
Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. US 9896517b2 [The United States authorized, 2018-02-20]
Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low-molecular-weight-glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. License 6293862 [Japan authorized, 2018-02-23]
Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low-molecular-weight- glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivate thereof. License 6248179 [Japan authorized, 2017-11-24]
Zhao JH, Kang H, Wu MY, Zeng WZ, Li Z, Gao Y, Cui J, Wang ZG, Feng HL, Yu, L. Depolymerized glycosaminoglycan from Thelenota ananas and preparation method thereof. AUS 2010324437 [Australian authorized, 2015-04-02].
Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Li Z, Lu F, Xu L, Xiao C, Yang L, Chen J, Zhou LT, Peng WL, Liu JK. Fuc3S4S substituted oligoglycosaminoglycan and preparation method thereof. WO 2015/103921 A1
Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Derivate of low molecular weight fucosylated glycosaminoglycan and medical composition and preparation method and application thereof. CN 103145868 B
Liu JK, Zheng YT, Zhao JH, Wu MY, Huang N, Li Z, Gao N, Wen DD, Lian W, He JB. Low molecular weight carboxyl-reduced derivatives of fucosylated glycosaminoglycans and preparation method and applications of low molecular weight carboxyl-reduced derivatives. CN 102558389 B
Zhao JH, Wu MY, Li Z. Composition containing dendrobium polysaccharide and atractylodes oil and application thereof. CN 103690582 B
Zhao JH, Wu MY, Gao N, Wen DD, Lian W, Li Z. Fucosylated glycosaminoglycan derivative and preparation method thereof. CN 102329397 B
Zhao JH, Wu MY, Li Z. Composition for treating digestive ulcer and applications thereof. CN 103735591 B
Zhao JH, He JX, Wu MY, Zhao LY, Liu ZW, Yang L, Li Z, Gao N, Xiao C, Xu L, Chen J, Zhou LT. Oligosaccharide compound inhibiting endogenous factor X enzyme activity and pharmaceutical composition thereof. CN 104370980 B
Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. 2,5-anhydrated talose or derivatives thereof terminal low-molecular-weight glycosaminoglycan derivative. CN 103214591 B
Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Li Z, Lu F, Xu L, Xiao C, Yang L, Chen J, Zhou LT, Peng WL, Liu JK. Fuc3S4S substituted oligo-glycosaminoglycan and preparation method thereof. CN 103788222 B
Awards and Recognition
Outstanding scientific and technological talents in the pharmaceutical industry of Guangdong Province for 30 years of reform and opening up (2008)
Yunnan high-end talent program (2010)
Hundred talent program of CAS (2011)
Academic research on F.Xase inhibitors was selected into the “Top Ten Progress” of Kunming Institute of Botany, Chinese Academy of Sciences (2015)
New drug technology transfer of LFG was selected into the “Top Ten Progress” (First Place) of Kunming Institute of Botany (2016)
The special allowance of Yunnan provincial government (2017)
Yunnan Province Science and Technology Award for Technological Invention, First Prize (2023)
