出生年月：1970.11 民族：汉族
学历学位：药学博士 职称：教授
学科专业：药理学
电话： 027-67842332
电子邮箱：hbtang2006@mail.scuec.edu.cn
研究方向包括：肝损伤机制及民族药物干预；皮肤创伤修复的民族药物药理学机制研究。
1996年毕业于湖南中医学院（现更名湖南中医药大学），获医学学士学位；同年任湖南株洲市中医伤科医院五官科医师；1998年9月赴日本国立广岛大学医学部留学，于2005年3月，获博士（药学）学位；2005年4月至2009年3月任广岛大学药学部助理教授；
在日本广岛大学任教期间，主持日本国家自然科学基金项目2项，并与Nippon Chemiphar、大鹏药品工业和协和发酵工业等几家主要药业公司合作开展扎托洛芬、紫杉醇等4项新药的研发工作。
2009年4月回国，任金沙威尼斯欢乐娱人城教授，并先后主持完成包括国家自然科学基金项目在内的各级研究项目70余项。
多年来主要从事包括肝癌在内肿瘤发生、发展的病理学机制及抗肿瘤民族药物的研究，以及包括修复皮肤重度创伤和银屑病、特应性皮炎、妊娠纹等慢性疑难皮肤疾患等药用敷料和轻医美的护肤功效性产品研发，并自主开发了皮肤自体快速再生与无痕修复技术SFO医美系列产品（从其应用场景而言，要么是独一无二，要么是遥遥领先），相关成果已获中国发明专利授权；在Nanomedicine NBM、Journal of Agricultural and Food Chemistry、International Journal of Nanomedicine、Neuropharmacology、Journal of Ethnopharmacology、Toxicology Research等期刊上发表论文70余篇，申报发明专利28项，其中24项已授权，并有糖尿病足溃疡无痕修复、快速去除妊娠纹、美白祛斑等13项技术已完成科技成果转化。
近五年的代表性研究论文（*为通讯作者）
1. Zhang Z, Ma SY, Yin X, Li YS, Tang HB*. Topical frankincense treatment for frostbite based on microcirculation improvements. Journal of Ethnopharmacology. 2025, 336:118728. doi: 10.1016/j.jep.2024.118728.
2. Yin X, Gu HW, Ning D, Li YS, Tang HB*. Testosterone Exacerbates the Formation of Liver Cancer Induced by Environmental N-Nitrosamines Exposure: Potential Mechanisms and Implications for Human Health. OncoTargets and Therapy. 2024, 17: 395-409. doi: 10.2147/OTT.S456746.
3. Zhai SY, Gu HW, Wang C, Li YS, Tang HB*. Gynura procumbens and selected metabolites: Amelioration of depressive-like behaviors in mice and risperidone-induced hyperprolactinemia in rats. Biomed Pharmacother. 2024, 173: 116361. doi: 10.1016/j.biopha.2024.116361.
4. Yin X, Li YS, Ye SZ, Zhang T, Zhang YW, Xi Y, Tang HB. Promotion Effect of Coexposure to a High-Fat Diet and Nano-Diethylnitrosamine on the Progression of Fatty Liver Malignant Transformation into Liver Cancer. International Journal of Molecular Sciences. 2023, 24(18): 14162. doi: 10.3390/ijms241814162.
5. Meng SS, Gu HW, Zhang T, Li YS, Tang HB*. Gradual deterioration of fatty liver disease to liver cancer via inhibition of AMPK signaling pathways involved in energy-dependent disorders, cellular aging, and chronic inflammation. Frontiers in Oncology. 2023, 13: 1099624. doi: 10.3389/fonc.2023.1099624.
6. Yin X, Hong J, Tang HB*, Liu M, Li YS. Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil. Frontiers in Pharmacology. 2022, 13: 913098. doi: 10.3389/fphar.2022.913098.
7. Wang C, Huang XL, Mu YM, Li YS, He YM, Tang HB*. Synergistic effects of trans-p-coumaric acid isolated from the ethanol extract of Gynura procumbens in promoting intestinal absorption of chlorogenic acid and reversing alcoholic fatty liver disease. Journal of Ethnopharmacology. 2022, 295: 115407. doi: 10.1016/j.jep.2022.115407.
8. Zhang T, Gu HW, Gao JX, Li YS, Tang HB*. Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment. Journal of Ethnopharmacology. 2022, 285: 114917. doi: 10.1016/j.jep.2021.114917.
9. Li YS, Zhang J, Tian GH, Shang HC, Tang HB*. Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens makino by inhibiting COX-2 expression and inflammatory cell infiltration. Journal of Ethnopharmacology. 2021, 268: 113547. doi: 10.1016/j.jep.2020.113547.
10. Hong J, Chen XZ, Peng YG, Zhang WK, Tang HB*, Li YS. Nanoparticle-Encapsulated Liushenwan Could Treat Nanodiethylnitrosamine-Induced Liver Cancer in Mice by Interfering With Multiple Critical Factors for the Tumor Microenvironment. Frontiers in Pharmacology. 2020, 11: 1052. doi: 10.3389/fphar.2020.01052.
11. Zheng L, Li XY, Huang FZ, Zhang XT, Tang HB*, Li YS, Zhang WK, Li XJ, Tian GH. Effect of electroacupuncture on relieving central post-stroke pain by inhibiting autophagy in the hippocampus. Brain Research. 2020, 1733: 146680. DOI: 10.1016/j.brainres.2020.146680.
12. Qin QF, Li XJ, Li YS, Zhang WK, Tian GH, Shang HC, Tang HB*. AMPK-ERK/CARM1 signaling pathways affect autophagy of hepatic cells in samples of liver cancer patients. Frontiers in Oncology. 2019, 9: 1247. DOI: 10.3389/fonc.2019.01247.
13. Huang XL, Li XJ, Qin QF, Li YS, Zhang WK, Tang HB*. Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material. Journal of Ethnopharmacology. 2019, 239: 111916. DOI: 10.1016/j.jep.2019.111916.
14. Chen MT, Zhang WK, Liang WL, Li YS, Li XJ, Zhu LH, Tang HB*. Controllable and extra-fast synthesis of bio-applicable silver nanoparticles with Lycium Barbarum L. Materials Technology. 2019, DOI: 10.1080/10667857.2019.1603656
15. Liang WL, Xiao L, Gu HW, Li XJ, Li YS, Zhang WK, Tang HB*. Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo. International Journal of Nanomedicine. 2019, 14: 1–13.
16. Li XJ, Huang FZ, Wan Y, Li YS, Zhang WK, Xi Y, Tian GH, Tang HB*. Lipopolysaccharide Stimulated the Migration of NIH3T3 Cells Through a Positive Feedback Between β-Catenin and COX-2. Frontiers in Pharmacology. 2018, 9: 1487.
17. Zhang MT, Ye XX, Lan W, Yang YL, Wu T, Li YS*, Tang HB. Strategic Combination of Isocratic and Gradient Elution for Simultaneous Separation of Polar Compounds in Traditional Chinese Medicines by HPLC. Journal of Analytical Methods in Chemistry. 2018, 2018: 7569283.
近年主持的国家自然科学基金项目
1. 基于β-catenin/COX-2炎性环路探究外用生肤油促进糖尿病足病快速修复的效应机制，2021年国家自然科学基金面上项目；
2. 平卧菊三七干预“β-catenin/COX-2”炎性环路的防治肝癌机制研究. 2016年国家自然科学基金面上项目；
3. 生肤油促进Ⅲ度烫伤皮肤无瘢痕修复的机制研究。2013年国家自然科学基金面上项目；
4. Wnt/β-catenin信号通路调控原发性肝癌发生的机制研究. 2011年国家自然科学基金青年项目；
5. 非神经细胞对背根神经节神经细胞内P物质释放的调控机制。2010年国家自然科学基金面上项目；
