出生年月：1972.12
民族：汉族
学历学位：医学博士
职称：教授
学科专业：病理学、药理学
电子邮箱：liys2006@mail.scuec.edu.cn
研究方向包括：肿瘤形成的病理学机制及抗肿瘤药物的干预研究；肝损伤机制及民族药物干预。
1997年毕业于湖南中医学院（现更名湖南中医药大学）临床医疗专业；1999年3月赴日本国立广岛大学医学部留学，于2006年3月，获人体病理学专业博士（医学）学位；2006年4月至2009年3月日本国立广岛大学大学院医学部任博士研究员；2009年4月任金沙威尼斯欢乐娱人城副教授；2016年6月任金沙威尼斯欢乐娱人城教授。多年来主要从事肿瘤发生、发展的病理学机制及抗肿瘤药物的药理学基础理论研究及镇痛新药的研究开发工作。回国后主要开展原发性肝癌发生、发展的病理学机制探讨及抗肝癌药物的药理学研究，主持或参与包括国家自然科学基金在内项目等十余项，并在Nanomedicine NBM、Toxicology Research、Journal of Agricultural and Food Chemistry、International Journal of Nanomedicine、Neuropharmacology等国际或国内学术刊物上发表了40余篇研究论文，获国家发明专利6项。
一、奖励
一等奖，论文题名“浸潤性微小乳頭癌的淋巴行性转移及血管新生因子的表达”；第13届日本乳腺癌学术总会，2005；
一等奖，论文题名“The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast”；第8届日本乳腺癌学会优秀论文奖，2007
二、近年代表性研究论文(*为通讯作者)
1.Huang XL, Li XJ, Qin QF, Li YS*, Zhang WK, Tang HB. Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material. Journal of Ethnopharmacology. 2019, 239:111916.DOI: 10.1016/j.jep.2019.111916
2.Chen MT, Zhang WK, Liang WL, Li YS, Li XJ, Zhu LH, Tang HB. Controllable and extra-fast synthesis of bio-applicable silver nanoparticles with Lycium Barbarum L. Materials Technology. 2019, DOI: 10.1080/10667857.2019.1603656
3.Liang WL, Xiao L, Gu HW, Li XJ, Li YS, Zhang WK, Tang HB. Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo. International Journal of Nanomedicine. 2019, 14: 3283-3295.
4.Li XJ, Huang FZ, Wan Y, Li YS, Zhang WK, Xi Y, Tian GH, Tang HB. Lipopolysaccharide stimulated the migration of NIH3T3 Cells through a positive feedback between β-catenin and COX-2. Frontiers in Pharmacology. 2018, 9: 1487.
5.Qin QF, Liu M, Tian GH, Chen J, Li YS*. Extract of the blood circulation-promoting recipe-84 can protect rat retinas by inhibiting the beta-catenin signaling pathway.International Journal of Molecular Sciences. 2018, 19: 2712.
6.Chen XZ, Zhang WK, Tang HB, Li XJ, Tian GH, Shang HC, Li YS*. The ethanol supernatant extracts of Liushenwan could alleviate nanodiethylnitrosamine-induced liver cancer in mice.Canadian Journal of Gastroenterology and Hepatology. 2018, 2018: 6934809.
7.Zhang MT, Ye XX, Lan W, Yang YL, Wu T, Li YS*, Tang HB. Strategic combination of isocratic and gradient elution for simultaneous separation of polar compounds in traditional Chinese medicines by HPLC.Journal of Analytical Methods in Chemistry. 2018, 2018: 7569283.
8.Li XJ, Mu YM, Qin QF, Zeng ZX, Li YS, Zhang WK, Tang HB*, Tian GH, Shang HC. Chronic high-dosage fish oil exacerbates gut–liver axis injury in alcoholic steatohepatitis in mice: the roles of endotoxin and IL-4 in Kupffer cell polarization imbalance.Toxicology Research. 2017, 6: 611–620.
9.Razzaque S, Cai C, Lu QW, Huang FZ, Li YS, Tang HB*, Hussaind I, Tan BE. Development of functionalized hollow microporous organic capsules encapsulating morphine – an in vitro and in vivo study. Journal of Materials Chemistry B. 2017, 5, 742-749
10.Chen MT, Yang YJ, Li YS, Li XJ, Zhang WK, Wang JP, Wang X, Tian GH, Tang HB*, Shang HC. Shengfu Oil Enhances the Healing of Full-Thickness Scalded Skin Accompanying the Differential Regulation of β-Catenin, Dlk1, and COX-2. Frontiers in Pharmacology. 2017, 8(801):1-10.
11.Ning D, Zhang WK, Tian H, Li XJ, Liu M, Li YS*, Tang HB. The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy. Journal of Ophthalmology. 2017, 2017(9760501): 1-12.
12.Zhang WK, Gu HW, Li XJ, Li YS*, Tang HB, Tian GH, Shang HC. The dark side of the force - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice. Nanomedicine: Nanotechnology, Biology, and Medicine. 2017, 13(2): 701-711.
13.Zhang WK, Tao SS, Li TT, Li YS, Li XJ, Tang HB, Cong RH, Ma FL, Wan CJ. Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo. Food & nutrition research. 2016, 60: 30849.
14.Li YS, Leng CL, Chen MT, Zhang WK, Li XJ, Tang HB, Shang HC, Zhu LH. Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway. Toxicology Research. 2016, 5:210-223.
15.Wan Y, Yang YJ, Li YS, Li XJ, Zhang W, Liu M, Tang HB. Effects of San-huang-sheng-fu oil on peripheral circulatory disorders and foot ulcers in diabetic rats and the mechanisms. Zhonghua Shao Shang Za Zhi. 2016, 32(3):168-75.
16.Li XJ, Yang YJ, Li TT, Li YS, Zhang WK, Tang HB, α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. Journal of Ethnopharmacology. 2016, 179:22-26.
17.Yang YL, Ye XX, Li YS*, Jiang JZ. Determination of morphine in pharmaceutical products by on-line solid-phase extraction and high-performance liquid chromatography. Analytical Letters. 2016, 49(9):1303-1309.
18.Li XJ, Mu YM, Li TT, Yang YL, Zhang MT, Li YS, Zhang WK, Tang HB, Shang HC. Gynura procumbens reverses acute and chronic ethanol-induced liver steatosis through MAPK/SREBP-1c-dependent and -independent pathways. Journal of Agricultural and Food Chemistry. 2015, 63(38):8460-8471.
19.Li YS, Xi Y, Li XJ, Leng CL, Jia MM, Zhang WK, Tang HB. Up-regulation of the biosynthesis and release of substance P through Wnt/β-catenin signaling pathway in rat dorsal root ganglion cells. PLoS One. 2015,10(6):e0129701.
20.Zhao XJ, Chen Q, Li YS*,Tang HB, Liu W, Yang XL. Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice.European Journal of Pharmaceutics and Biopharmaceutics. 2015, 93: 27-36.
21.Zhao XJ, Chen Q, Liu W, Li YS*, Tang HB, Liu XH and Yang XL. Co-delivery of doxorubicin and curcumin withlipid nanoparticles results in improved efficacy of chemotherapy in liver cancer. International Journal of Nanomedicine. 2015, 10: 257–270.
22.Li YS, Chen BF, Li XJ, Zhang WK, Tang HB. Cytotoxicity of polyaniline nanomaterial on rat celiac macrophages in vitro. PLoS One. 2014, 9(9):e107361.
23.Li XJ, Jia MM, Li YS*, Yang YL, Mao XQ, Tang HB. Involvement of substance p/neurokinin-1 receptor in the analgesic and anticancer activities of minimally toxic fraction from the traditional Chinese medicine Liu-Shen-Wan in vitro.Biol Pharm Bull. 2014, 37(3):431-438.
24.Xi Y, Li YS*, Tang HB. High mobility group A1 protein acts as a new target of Notch1 signaling and regulates cell proliferation in T leukemia cells. Mol Cell Biochem. 2013, 374: 173-180.
25.Jia MM,Li YS, Pei LJ, Liu M, Li XJ, Tang HB. Effect of San-huang-sheng-fu oil on wounds of full-thickness scald in rabbits. Zhonghua Shao Shang Za Zhi. 2013, 29(1): 50-54.
26.Li YS, Wang JX, Jia MM, Liu M, Li XJ, Tang HB. Dragon's Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats. Journal of Pharmacological Sciences. 2012,118: 43-54.
27.Li YS, Liu M, Nakata Y,Tang HB. β-Catenin accumulation in nuclei of hepatocellular carcinoma cells up-regulates glutathione-s-transferase M3 mRNA.World Journal of Gastroenterology. 2011, 17: 1772-1778.
三、近年主持或参与的国家自然科学基金项目
1. 平卧菊三七干预“β-catenin/COX-2”炎性环路的防治肝癌机制研究. 2016年国家自然科学基金面上项目；
2. 电针对CPSP大鼠星形胶质细胞介导的Wnt/β-catenin信号通路调控作用. 2016年国家自然科学基金面上项目
3. 六神丸干预“β-catenin与COX-2环路”的镇癌痛机制研究. 2015年国家自然科学基金面上项目；
4. 基于Wnt/β-catenin靶点的益气活血方抗糖尿病视网膜病变作用机制研究。2012年国家自然科学基金青年项目；
5. Wnt/β-catenin信号通路调控原发性肝癌发生的机制研究. 2011年国家自然科学基金青年项目；
6. 非神经细胞对背根神经节神经细胞内P物质释放的调控机制。2010年国家自然科学基金面上项目；
