出生年月:1981.10.25
民族:汉
职称:副教授
学科专业:药物化学、药物分析
研究方向:水溶性荧光纳米材料的合成及其在药物分析中的应用研究
电子邮箱:wqzhdpai@163.com
学习经历
1999 -2003 就读于华中师范大学化学学院,获理学学士学位
2004-2009 硕博连读于武汉大学化学与分子科学学院分析化学专业 获得博士学位
2007 -2008 作为交换生及研究助理在香港浸会大学化学系从事研究工作
工作经历
2009年至今任教于金沙威尼斯欢乐娱人城现为金沙威尼斯欢乐娱人城药学院教师,主要从事分析化学、化学生物学方面的教学和科研工作。
承担的重要项目:
水溶性手性量子点的制备及双色荧光法手性药物检测研究、国家自然科学基金青年项目、国家自然科学基金委,2012-2014年,主持
基于量子点荧光可逆变化模式的铂类抗癌药物检测研究、湖北省自然科学基金青年项目、湖北省科技厅,2011-2013年,主持
基于量子点荧光“turn off-on”可逆模式的G-四链体与靶向抗癌药物作用研究、湖北省自然科学基金面上项目、湖北省科技厅,2016 -2017年,主持
近期发表的部分论文目录:
1.Fang Gao, Shiyao Ma, Xincai Xiao, Yan Hu, Dan Zhao*, Zhike He. Sensing Tyrosine Enantiomers by Using Chiral CdSe/CdS Quantum Dots Capped with N-acetyl-L-cysteine. Talanta. 2017, 163, 102–110.
2.Xiaoling Xu, Shiyao Ma, Xincai Xiao, Yan Hu, Dan Zhao*. The Preparation of High-quality Water-soluble Silicon Quantum Dots and Their Application in the Detecion of Formaldegyde. RSC Advances. 2016, 6, 98899-98907.
3.Fang Gao, Shiyao Ma, Jun Li, Kang Dai, Xincai Xiao, Dan Zhao*, Weifan Gong. Rational Desigh of High Quality Citric Acid-derived Carbon Dots by Selecting Eddicient Chemical Structure Motifs. Carbon. 2017, 112, 131-141.
4.Dan Zhao, Yao Fan, Fang Gao, Tianming Yang. “Turn-off-on” fluorescent sensor for (N-methyl-4-pyridyl) porphyrin-DNA and G-quadruplex interactions based on ZnCdSe quantum dots. Analytica Chimica Acta. 2015, 888, 131-137.
5.Dan Zhao, Jiaotian Li, Tianming Yang, Zhike He. “Turn off-on” fluorescent sensor for platinum drugs-DNA interactions based on quantum dots. Biosensors and Bioelectronics. 2014,52, 29–35
6.赵丹郝键国家专利:一种水溶性手性CdTe量子点的制备方法。专利号: ZL 201110217909.9 2014年,已授权。
7.洪宗国赵丹国家专利:含CdTe量子点的纳米青蒿琥酯胶囊及其制备方法,专利号:ZL 2011 1 0281330.9。2013年,已授权。
8.Dan Zhao, Jiao-Tian Li, Fang Gao, Cui-ling Zhang and Zhi-ke He. Facile synthesis and characterization of highly luminescent UV-blue-emitting ZnSe/ZnS quantum dots via a one-step hydrothermal method. RSC Advances. 2014, 4, 47005-47011.
9.Jiaotian Li, Tianming Yang, W. H. Chan, Martin M. F. Choi, Dan Zhao*. Synthesis of High-Quality N‑Acetyl‑L‑Cysteine-Capped CdTe Quantum Dots by Hydrothermal Route and the Characterization through MALDI-TOF Mass Spectrometry. Journal of Physical Chemistry C. 2013, 117, 19175−19181
10.Fang Gao, Yuying Liu, Yao Fan and Dan Zhao*. Synthesis of N-acetyl-L-cysteine -capped ZnCdSe quantum dots via hydrothermal method and their characterization. Science and Technology of Advanced Materials. 2014,15,055001 (9pp).
11.Fang Gao, Jiaotian Li, Fengxue Wang, Tanming Yang, Dan Zhao*. Synthesis and characterization of high-quality water-soluble CdMnTe quantum dots capped by N-Acetyl-L-Cysteine via hydrothermal method. Journal of Luminescence. 2015,159,32–37.
12.Tianming Yang, Qingyi He, Yuying Liu, Chaozhen Zhu, Dan Zhao*. Water-Soluble N-Acetyl-L-cysteine-Capped CdTe Quantum Dots Application for Hg(II) Detection. Journal of Analytical Methods in Chemistry. 2013,6,1-6.
13.Dan Zhao, Yang Fang, Haoyuan Wang and Zhike He. Synthesis and characterization of high-quality water-soluble CdTe: Zn2+ quantum dots capped by N-acetyl-L-cysteine via hydrothermal method. J. Mater. Chem.,2011, 21, 13365–13370
14.Dan Zhao, Zhike He, PuiShanChan, Ricky N. S. Wong, Lee, Albert NaiKi Mak, HangKei Mak, and WingHong Chan. NAC-Capped Quantum Dot as Nuclear Staining Agent for Living Cells Via an In Vivo Steering Strategy. Journal of Physical Chemistry C. 2010, 114, 6216–6221.
15.Dan Zhao, Wing Hong Chan, Zhike He, Ting Qiu. Quantum dot-ruthenium complex dyads: recognition of double-Strand DNA through dual-color fluorescence detection. Analytical Chemistry. 2009, 81, 3537-3543.
16.Dan Zhao, Zhike He, WingHong Chan, Martin M. F. Choi. Synthesis and characterization of high-quality water-soluble near-infrared- emitting CdTe/CdS quantum dots capped by N-acetyl -L-cysteine via hydrothermal method. Journal of Physical Chemistry C. 2009, 113, 1293-1300.
17.Dan Zhao, Juan Du, Yanguo Chen, Xinghu Ji, Zhike He, WingHong Chan. A quencher -tether-ligand probe and its application in biosensor based on conjugated polymer. Macromolecules. 2008, 41, 5373 -5378.
18.Lehui Xiao, Dan Zhao, Wing-Hong Chan, Martin M.F. Choi, Hung-Wing Li. Inhibition of beta 1-40 amyloid fibrillation with N-acetyl –L-cysteine capped quantum dots. Biomaterials. 2010, 31, 91-98.
19.Ting Qiu, Dan Zhao, Guohua Zhou, Yuan Liang, Zhike He, Zhihong Liu, Xiaoniu Peng, Li Zhou. A positively charged QDs-based FRET probe for micrococcal nuclease detection. Analyst. 2010, 135, 2394–2399.
20. Yanguo Chen, Dan Zhao, Zhike He, Xinping Ai. Fluorescence quenching of water-soluble conjugated polymer by metal cations and its application in sensor. Spectrochimica Acta Part A.2007, 66, 448-452.