熊 慧
出生年月：1986.08
民族：汉
职称：副教授
专业：药学
邮箱：xionghui0311020@163.com
在团队负责人梅之南教授的带领下，主要从事中药及民族药的药效物质基础与作用机制研究。近年来承担和参与了国家重点研发任务、国家自然科学基金、湖北省科技重大专项、科技创新专项等省部级项目 10 余项；在Hepatology，Phytomedicine等期刊上发表论文 20 余篇；获得民族医药学会和湖北省科技进步奖二等奖各1项。
教育经历
2010-09至2013-07，华中科技大学，药学院，博士
2007-09至2010-07，金沙威尼斯欢乐娱人城，药学院，硕士
2003-09至2007-07，广西中医学院，药学院，学士
工作经历
2014-03至今于金沙威尼斯欢乐娱人城工作
主持或参加科研项目（课题）情况
1. 湖北省科技厅，湖北省科技重大专项，湖北中药质控标准物质研制及技术平台建立，ZDZX2020000002，2020-07至2023-06，140 万元，在研，课题负责人
2. 湖北省科技厅，湖北省创新专项重点项目，BZZ19005，传统藏药三味蔷薇散治疗胆囊炎的系统生物学研究，2020-01至2022-12，20 万元，在研，主持
3. 国家科学技术部，国家重点研发计划中医药现代化研究重点专项课题，壮医药等治疗强直性脊柱炎研究，2018YFC1708004，2018-12至2021-11，50 万，在研，子课题负责人
4. 国家自然科学基金委员会，青年基金，31600272，榼藤调控A20/NF-κB信通路的活性成分解析及其抗类风湿关节炎作用机制研究，2017-01至2019-12，19 万元，结题，主持
5. 湖北省科技厅，青年基金，2016CFB189，基于化学物质组学榼藤抗类风湿性关节炎药效成分群及相互作用研究，2016-01至2017-12，5 万元，结题，主持
此外，主持并完成横向项目多项。
代表性研究成果和学术奖励情况
一、代表性论著
1. Jinhong Xu #, Hui Xiong #, Zhongqiu Zhao, Miao Luo, Yankun Ju, Guangzhong Yang *, Zhinan Mei *. Genistein suppresses allergic contact dermatitis through regulating the MAP2K2/ERK pathway. Food & Function, 2021, DOI:10.1039/D0FO03238G (IF 4.171)
2. Hui Xiong, Miao Luo, Yankun Ju, Zhongqiu Zhao, Man Zhang, Ran Xu, Yongshen Ren, Guangzhong Yang, Zhinan Mei *. Triterpene saponins from Guo-gang-long attenuate collagen-induced arthritis via regulating A20 and inhibiting MAPK pathway. J Ethnopharmacol, 2021, 6;269:113707 (IF 3.690)
3. Chuyue Tu #, Hui Xiong #, Yufeng Hu #, Wen Wang, Gui Mei, Hua Wang, Ya Li, Zelin Zhou, Fengping Meng, Peng Zhang *, Zhinan Mei*. Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation. Hepatology, 2020, 72(6): 1949-1965 (IF 14.679)
4. Xuechuan Xiang, Chuyue Tu, Qiaoyun Li, Wen Wang, Xiaoqin Huang, Zhongqiu Zhao, Hui Xiong *, Zhinan Mei *. Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes. Toxicol Appl Pharmacol, 2020, 15;405:115209 (IF 3.347)
5. Hui Xiong, Xin Ding, Hua Wang, Haiqin Jiang, Xinyan Wu, Chuyue Tu, Chaoqun Wu, Yang Pi, Guangzhong Yang, Zhongqiu Zhao, Zhinan Mei*. Tibetan medicine Kuan-Jin-Teng exerts anti-arthritic effects on collagen-induced arthritis rats via inhibition the production of pro-inflammatory cytokines and down-regulation of MAPK signaling pathway. Phytomedicine, 2019, 57:271-281 (IF 4.268)
6. Sisi Liu #, Xueting Liu #, Hui Xiong #, Wen Wang, Yutong Liu, Liang Yin, Chuyue Tu, Hua Wang, Xuechuan Xiang, Jinhong Xu, Bailu Duan, Ailin Tao, Zhongqiu Zhao, Zhinan Mei *, CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice. Brain, Behav., Immun., 2019, 80:711-724 (IF 6.633)
7. Xuan Gong #, Hui Xiong #, Sisi Liu, Yutong Liu, Liang Yin, Chuyue Tu, Hua Wang, Zhongqiu Zhao, Weiwu Chen, Zhinan Mei *, Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis. Front. Pharmacol., 2019, 10: 354 (IF 4.225)
8. Hui Xiong #, Shengnan Zhang #, Zhongqiu Zhao, Ping Zhao, Lvyi Chen, Zhinan Mei *, Antidiabetic activities of entagenic acid in type 2 diabetic db/db mice and L6 myotubes via AMPK/GLUT4 pathway. J Ethnopharmacol, 2018, 211:366-374 (IF 3.690)
9. Yanan Zheng, Xuefei Yin, Fuquan Huo, Zhinan Mei *, Hui Xiong *. Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomisrotata (Benth.) Kudo in rats with spared nerve injury. J Ethnopharmacol, 2015, 173:204-211 (IF 3.690)
10. Hui Xiong, Yanan Zheng, Guangzhong Yang, Zhinan Mei *. Triterpene saponins with anti-inflammatory activity from the stems of Entada phaseoloides. Fitoterapia, 2015, 103:33-45 (IF 2.257)
二、学术奖励
熊慧（序 1）；土家药的药效物质基础与应用，中国民族医药学会科技进步奖，二等奖，2020
熊慧（序 6）；基于中药智能制造技术的七叶皂苷钠创新研发及其产业化，湖北省科技进步奖，二等奖，2018
