出生年

1988.10

民族

汉

职称

副教授

学科专业

生物医学工程

研究方向

神经生物学

电子邮箱

jiawei-min@hotmail.com

简历

博士，副教授，硕士生导师。2016年6月博士毕业于武汉大学基础医学院。毕业后先后在美国Sanford School of Medicine, University of South Dakota和美国University of Texas Health Science Center at Houston任博士后研究员，2019年10月回国加盟金沙威尼斯欢乐娱人城生物医学工程学院。现为美国心脏协会(AHA)会员，中国神经科学学会会员，湖北省生理学会会员，武汉市生理学会理事。并受邀成为SCI期刊《Frontiers in Pharmacology》和《Journal of Integrative Neuroscience》的客座编辑且多次担任SCI杂志Stroke; Iscience; Brain Research Bulletin; Clinical Epidemiology; Neuroreport; Journal of Molecular Neuroscience等审稿人。同时，担任教育部学位与研究生教育发展中心评审专家。近年来发表SCI论文20多篇，其中第一作者或通讯作者14篇，总引用超过1000余次，其中ESI高引1篇。目前主持国家自然科学基金项目1项、湖北省自然科学基金项目2项、中央高校基本科研业务费专项资金项目1项、金沙威尼斯欢乐娱人城引进人才项目1项，并参与多个国家级和省级项目。本课题组主要研究领域为新生儿缺氧缺血性脑病和成年人缺血性脑卒中的发病机制及靶向干预的研究。专注于①探究钙/钙调蛋白依赖性蛋白激酶激酶β（CaMKKβ）在上述两种疾病中的神经保护作用及其机制；②利用网络药理学、分子对接、SPR、代谢组学和转录组学等技术，筛选具有改善上述两种疾病的小分子化合物或中药单体。

近年代表性研究成果（论文、专著、获奖、专利等）

第一作者或者通讯作者文章（#为共同一作；*为通讯作者）：

1. Liu XJ, Zheng D, Chen L, Chen S*, Min JW*. Nuclear Factor Erythroid 2-Related Factor 2 as a Potential Therapeutic Target in Neonatal Hypoxic-Ischemic Encephalopathy. J Integr Neurosci. 2024, 23(5), 103.

2. Chen L, Chen S, Yang XF, Min JW*. Antioxidants attenuate mitochondrial oxidative damage through the Nrf2 pathway: A promising therapeutic strategy for stroke. J Neurosci Res 2023. 101(8), 1275–1288.

3. Li Y, Chen L, Zheng D, Liu JX, Liu C, Qi SH, Hu PC, Yang XF and Min JW*. Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/ Nrf2 signaling pathway. Front. Pharmacol. (2023)14:1103265.

4. Li Y, Zhang JJ, Chen RJ, Chen L, Chen S, Yang XF, Min JW*. Genistein Mitigates Oxidative Stress and Inflammation by Regulating Nrf2/HO-1 and NF-κB Signaling Pathways in Hypoxic-Ischemic Brain Damage in Neonatal Mice. Ann Transl Med. 2022 Jan;10(2):32.

5. Zhang JJ, Li Y, Chen S, Yang XF, Min JW*. Biphalin, a dimeric opioid peptide, reduces neonatal hypoxia-ischemia brain injury in mice by the activation of PI3K/Akt signaling pathway. J Chem Neuroanat. 2021 Sep;115:101967.

6. Liu Y#, Min JW#, Feng S, Subedi K, Qiao F, Mammenga E, Callegari E, Wang H.Therapeutic Role of a Cysteine Precursor, OTC, in Ischemic Stroke Is Mediated by Improved Proteostasis in Mice. Transl Stroke Res. 2020 Feb;11(1):147-160.

7. Min JW, Bu F, Qi L, Munshi Y, Kim GS, Marrelli SP, McCullough LD, Li J. Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase β Is Detrimental in Hypoxia⁻Ischemia Neonatal Brain Injury. Int J Mol Sci. 2019 Apr 26;20(9):2063.

8. Min JW, Liu Y, Wang D, Qiao F, Wang H. The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. J Neurochem. 2018 Feb;144(3):336-347.

9. Min JW, Kong WL, Han S, Bsoul N, Liu WH, He XH, Sanchez RM, Peng BW. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. Oncotarget. 2017 Apr 11;8(15):25513-25524.

10. Min JW, Lü L, Freeling JL, Martin DS, Wang H. USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice. J Neurochem. 2017 Mar;140(5):826-833.

11. He M#, Min JW#, Kong WL, He XH, Li JX, Peng BW. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016 Dec;115:74-85. （ESI高引）

12. Min JW, Hu JJ, He M, Sanchez RM, Huang WX, Liu YQ, Bsoul NB, Han S, Yin J, Liu WH, He XH, Peng BW. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. Neuropharmacology. 2015 Dec;99:38-50.

13. Min JW, Peng BW, He X, Zhang Y, Li JX. Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. Eur J Pharmacol. 2013 Oct 15;718(1-3):81-6.

14. Min JW, Liu WH, He XH, Peng BW. Different types of toxins targeting TRPV1 in pain. Toxicon. 2013 Sep