姓名：赵平

职务/职称：副教授

E-mail：p.zhao@scuec.edu.cn

一、学习及工作经历

2010.7-至今，金沙威尼斯欢乐娱人城生命科学学院，副教授，硕士生导师

2006.11-2010.7，澳大利亚，新南威尔士大学，Garvan医学研究所，博士后

2001.09-2006.07，华中科技大学生物物理学专业，博士

二、主要社会兼职

湖北省生理学会理事，武汉市生理学会理事

三、科研活动及成果

（一）主要研究方向

糖尿病药物筛选及机理研究

（二）主持的科研项目

国家自然科学基金面上项目2项。湖北省自然科学基金项目1项。中央高校基本科研业务费专项基金项目5项。横向课题3项。

（三）代表性论文

1. Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang*, Ping Zhao*. Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation. Food Science and Human Wellness. 12 (2023) 2040-2051.

2. Yanhong Yao#, Xinzhou Yang, Jinhua Shen and Ping Zhao*. Glucose Uptake Is Increased by Estradiol Dipropionate in L6 Skeletal Muscle Cells. Pharmaceuticals. 2023, 16, 25.

3. Jingya Liao# , Ziwei Yang# , Yanhong Yao , Xinzhou Yang , Jinhua Shen and Ping Zhao*. Andrographolide Promotes Uptake of Glucose and GLUT4 Transport through the PKC Pathway in L6 Cells. Pharmaceuticals. 2022, 15, 1346.

4. Guanjun Song^#, Yun Huang^#, Mingrui Xiong, Ziwei Yang, Qinghua Liu, Jinhua Shen1, Ping Zhao* and Xinzhou Yang* Aloperine Relieves Type 2 Diabetes Mellitus via Enhancing GLUT4 Expression and Translocation. Frontiers in Pharmacology. 25 January 2021. Volume 11, Article 561956.

5. Yibing Lv^#, Ping Zhao^#, Kejian Pang, Yuanren Ma, Huiqi Huang, Tongxi Zhou, Xinzhou Yang*. Antidiabetic effect of a flavonoid-rich extract from Sophora alopecuroides L. in HFD- and STZ- induced diabetic mice through PKC/GLUT4 pathway and regulating PPARα and PPARγ expression. Journal of Ethnopharmacology. 2021 Mar 25;268:113654.

6. Ping Zhao^#,*, Liu Jia ^#, Qian Ming, Di Tian, Jingwen He, Ziwei Yang, Jinhua Shen, Qing-Hua Liu, Xinzhou Yang^*. Dandelion Extract Relaxes Mouse Airway Smooth Muscle via the Blockade of VDLCC and NSCC Channels. Cell & Bioscience. 2020, 10: 125.

7. Ping Zhao ^#,*, Di Tian ^#, Guanjun Song, Qian Ming, Jia Liu, Jinhua Shen, Qing-Hua Liu and Xinzhou Yang^*. Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells. Frontiers in Pharmacology. 04 September 2019,10: 999.

8. Lv YB^#, Ming Q, Hao J, Huang Y, Chen H, Wang Q, Yang XZ^*, Zhao Ping^*. Anti-diabetic activity of canophyllol from Cratoxylum cochinchinense (Lour.) Blume in type 2 diabetic mice by activation of AMP-activated kinase and regulation of PPARγ. Food & Function. 2019 Feb 20;10(2):964-977.

9. Ping Zhao ^#,*, Qian Ming ^#, Junying Qiu, Di Tian, Jia Liu, Jinhua Shen, Qing-Hua Liu and Xinzhou Yang^*. Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2+. Molecules. 2018, 23(11), 2934.

10. Ping Zhao^#,*, Qian Ming^#, Mingrui Xiong^#, Guanjun Song, Li Tan, Di Tian, Jia Liu, Zhao Huang, Jingyi Ma, Jinhua Shen, Qing-Hua Liu, Xinzhou Yang^*. Dandelion chloroform extract promotes glucose uptake via the AMPK/GLUT4 pathway in L6 cells. Evidence-Based Complementary and Alternative Medicine. 2018 Nov 7;2018:1709587.

11. Hao Xu^#, Ping Zhao^#, Wen-Jing Zhang^#, Jun-Ying Qiu^#, Li Tan, Xiao-Cao Liu, Qian Wang, Xi Luo, Yu-Shan She, Dun-An Zang, Bei-Bei Liu, Lei Cao, Xiao-Xue Zhao, Yuan-Yuan Chen, Meng-Yue Li, Jinhua Shen, Yong-Bo Peng, Lu Xue, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Gangjian Qin, Qing-Hua Liu^* . Generation and role of oscillatory contractions in mouse airway smooth muscle. Cell Physiol Biochem. 2018 Jun 25;47(4):1546-1555.

12. Mingrui Xiong^#, Yun Huang^#,Yajing Liu, Mi Huang, Guanjun Song, Qian Ming, Xinhua Ma, Jie Yang, Shihao Deng, Yanzhang Wen, Jinhua Shen, Qing-Hua Liu, Ping Zhao^*, Xinzhou Yang^*. Antidiabetic activity of Ergosterol from Pleurotus ostreatus in KK-Ay Mice with Spontaneous Type 2 Diabetes Mellitus. Molecular Nutrition and Food Research. 2018 Feb;62(3).

13. Yunfang Li^#, Ping Zhao^#, Yu Chen, Yanze Fu, Kuan Shi, Liu Liu, Hui Liu, Mingrui Xiong, Qing-Hua Liu, Guangzhong Yang^* , Yuxiu Xiao^*. Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes. Bioorganic & Medicinal Chemistry. 25 (2017) 6605-6613

14. Jialin Wang^#, Mi Huang^#, Jie Yang, Xinhua Ma, Sijian Zheng, Shihao Deng, Yun Huang, Xinzhou Yang^*, Ping Zhao^*. Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter. FOOD & NUTRITION RESEARCH, 2017 VOL. 61,

15. Wu YF^#，Zhao P^#, Luo X^#, Xu JC, Xue L, Zhou Q, Xiong M, Shen J, Peng YB, Yu MF, Chen W, Ma L，Liu Q-H^*. Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes. Cell & Bioscience. 201705.

16. Yang X#, Deng S#, Huang M, Wang J, Chen L, Xiong M, Yang J, Zheng S, Ma X, Zhao P*, Feng Y*, Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities, Bioorganic & Medicinal Chemistry Letters (2017), 2017 Mar 15;27(6):1463-1466

17. Yang X^#, Huang M, ^# Cai J, Lv D, Lv J, Zheng S, Ma X, Zhao P^*, Wang Q^*. Chemical profiling of anti-hepatocellular carcinoma constituents from Caragana tangutica Maxim. by off-line semi-preparative HPLC-NMR. Nat Prod Res. 2017; 31(10):1150-1155.

18. Qi Zhou^#, Xinzhou Yang^#, Mingrui Xiong, Xiaolan Xu, Li Zhen, Weiwei Chen, Yan Wang, Jinhua Shen, Ping Zhao^*, Qing-Hua Liu^*. Chloroquine Increases Glucose Uptake via Enhancing GLUT4 Translocation and Fusion with the Plasma Membrane in L6 Cells. Cellular Physiology and Biochemistry. 2016 May 9. 38: 2030-2040.

19.Yang X^#, Yang J^#, Xu C, Huang M, Zhou Q, Lv J, Ma X, Ke C, Ye Y, Shu G^*, Zhao P^*. Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice. Journal of Ethnopharmacology. 2015 June 5. 171: 161-170.  

20. Jing Yang^#, Xinzhou Yang^*, Chao Wang, Qinxiong Lin, Zhinan Mei, Ping Zhao^*. Sodium-glucose-linked transporter 2 inhibitors from Sophora flavescens. Medicinal Chemistry Research. 2015 March. 24: 1265-1271.

21. Jing Yang^#, Ping Zhao^#, Qi Zhou, Chao Wang, Dingrong Wan, Guangwen Shu, Zhinan Mei, Xinzhou Yang^*. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. Via Activation of AMP-activated Protein Kinase in Type 2 Diabetic Mice. Evidence-based Complementary and Alternative Medicine. 2014 September 2.

22. Ping Zhao^#, Lu Yang^#, Jamie A. Lopez, Junmei Fan, James G. Burchfield, Li Bai, Wanjin Hong, Tao Xu^* and David E. James^*. Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. J Cell Sci. 2009 October 122: 3472-3480.

23. Ping ZHAO^#, Wei LI^#, Yong-Ming DONG^#, Dan ZHU, An-Lian QU, Tao XU, and Zheng-Xing WU^*. Kir6.2ΔC26 channel traffics to plasma membrane by constitutive exocytosis. Acta Biochim Biophys Sin. 2006 Feb; 38(2):136-41.

24. Hu ZT^#, Zhao P^#, Liu J^#, Wu ZX^*, Xu T^*. Alpha-latrotoxin triggers extracellular Ca2+-dependent exocytosis and sensitizes fusion machinery in endocrine cells. Acta Biochim Biophys Sin. 2006 Jan; 38(1):8-14.

（四）授权专利

1. 一种蒲公英氯仿提取物及其制备方法和用途。申请人：赵平，熊明睿，刘庆华，谈丽。专利号：ZL 201710286429.5授权日：2020.05.15

2. GLUT4基因敲除的sgRNA、A459细胞系及其构建方法。申请人：赵平，刘佳，张颖。专利号：ZL201910614661.6 授权日：2021.06.15

3. 红花有机溶剂部提取物在制备气道平滑肌舒张药物中的应用。申请人：刘庆华，赵平，谈丽。专利号：ZL201410810748.8授权日：2014.12.23

4. 一种治疗糖尿病的药物组合物及其制备方法和用途。申请人：杨新洲，黄蕴 赵平，郑思建，黄密。专利号：ZL201710577168.2授权日：2018.10.26

5. 一种白刺花黄酮提取物及其制备方法和用途。申请人：杨新洲，黄蕴，宋萍，赵平，田迪，郝吉，吕奕兵。专利号：ZL201810717809.4授权日：2021.08.13

6. 竹黄乙酸乙酯萃取物用于制备防治糖尿病药物的用途。申请人：杨新洲，周琦，杨静，赵平，黄密。专利号：ZL201510473612.7授权日：2018.09.28

四、教学活动及成果

（一）承担课程

本科生课程：分子生物学；基因工程实验；生物化学实验。

研究生课程：科技论文写作；生物仪器分析。

（二）教学成果

主持教育部供需对接就业育人项目一项。主持校级教研教改项目6项。发表教改论文9篇。指导省级大学生创新创业训练项目5项。指导全国大学生生命科学竞赛省级二等奖一项。