姓名：高超

职务/职称：教授（硕/博导）

通讯地址：金沙威尼斯欢乐娱人城生命科学学院8号楼A502

E-mail：gaoc@scuec.edu.cn

一、研究领域和方向

目前在研的课题包括：

1、肾脏发育过程中的表观遗传调控。

2、慢性肾病致病的分子机制。

3、肾脏类器官构建。

二、教育背景

2010.09—2015.06，中国科学技术大学，生命科学学院，生物化学与分子生物学专业，博士

2005.09—2009.06，合肥工业大学，生物技术专业，理学学士

三、工作简历

2023.02—至今 金沙威尼斯欢乐娱人城生命科学学院，教授

2022.03—2022.10 美国奥尔巴尼医学院，ResearchAssociate

2016.03—2022.02 美国奥尔巴尼医学院，博士后

四、发表论文（*通讯作者）

1. Tsilosani A,Gao C, Chen E, Lightle A, Shehzad S, Sharma M, Tran P, Bates C, Wallace D, Zhang W. Pkd2 Deficiency in Embryonic Aqp2+ Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease.J Am Soc Nephrol. 2024;35(4):p 398-409. (IF 13.6)

2.Zhang W,Gao C, Tsilosani A, Samarakoon R, Plews R, and Higgins PJ. Potential renal stem/progenitor cells identified by in vivo lineage tracing.Am J Physiol Renal Physiol.2022;322(4):F379-F91.(IF 4.2)

3.Gao C, Zhang L, Chen E, and Zhang W. Aqp2(+) Progenitor Cells Maintain and Repair Distal Renal Segments.J Am Soc Nephrol.2022;33(7):1357-76.(IF 13.6)

4.Tsilosani A,Gao C, and Zhang W. Aldosterone-Regulated Sodium Transport and Blood Pressure.Front Physiol.2022;13:770375.(IF 4.755)

5.Gao C, Chen L, Chen E, Tsilosani A, Xia Y, and Zhang W. Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.J Am Soc Nephrol.2021;32(12):3035-49.(IF 13.6)

6.Heiserman JP, Nallanthighal S, Gifford CC, Graham K, Samarakoon R,Gao C, et al. Heat Shock Protein 27, a Novel Downstream Target of Collagen Type XI alpha 1, Synergizes with Fatty Acid Oxidation to Confer Cisplatin Resistance in Ovarian Cancer Cells.Cancers (Basel).2021;13(19).(IF 6.639)

7.Gao C, Higgins PJ, and Zhang W. AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions.Cells.2020;9(10).(IF 7.666)

8.Zhang L, Chen L,Gao C (joint first author), Chen E, Lightle AR, Foulke L, et al. Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2.J Am Soc Nephrol.2020;31(2):337-49.(IF 13.6)

9.Gao C, and Zhang W. Urinary AQP5 is independently associated with eGFR decline in patients with type 2 diabetes and nephropathy.Diabetes Res Clin Pract.2019;155:107805.(IF 8.18)

10.Chen L,Gao C (joint first author), Zhang L, Zhang Y, Chen E, and Zhang W. Highly tamoxifen-inducible principal cell-specific Cre mice with complete fidelity in cell specificity and no leakiness.Am J Physiol Renal Physiol.2018;314(4):F572-F83.(IF 4.2)

11.Gao C, Zhang L, Zhang Y, Wallace DP, Lopez-Soler RI, Higgins PJ, et al. Insights into cellular and molecular basis for urinary tract infection in autosomal-dominant polycystic kidney disease.Am J Physiol Renal Physiol.2017;313(5):F1077-F83.(IF 4.2)

12.Liu J,Gao C (joint first author), Chen W, Ma W, Li X, Shi Y, et al. CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation.Transl Psychiatry.2016;6(1):e703.(IF 7.989)

13.Ma W, Li C, Yin S, Liu J,Gao C, Lin Z, et al. Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in human hepatoma cells.Free Radic Biol Med.2015;89:1003-13.(IF 8.1)

14.Gao C, Yu Q, Xu H, Zhang L, Liu J, Jie Y, et al. Roles of the lateral fenestration residues of the P2X(4) receptor that contribute to the channel function and the deactivation effect of ivermectin.Purinergic Signal.2015;11(2):229-38.(IF 3.95)

15.Jie Y, Zhang L, Xu H,Gao C, Ma W, and Li Z. Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement.Neurosci Lett.2014;582:1-5.(IF 3.2)

16.Zhang L, Xu H, Jie Y,Gao C, Chen W, Yin S, et al. Involvement of ectodomain Leu 214 in ATP binding and channel desensitization of the P2X4 receptor.Biochemistry.2014;53(18):3012-9.(IF 3.321)

五、获批专利

1.李志远，高超，刘静馨。一种快速增加细胞膜通透性的细胞内液及其方法。2018.06.19，中国，CN104911241B